Disclaimer:I am not, nor do I even know, any of the authors of the following study:Optimal control strategies for tuberculosis treatment: a case study in AngolaIn fact I have not even read the paper, only the posting Comments on arxiv:"We apply optimal control theory to a tuberculosis model given by a system of ordinary differential equations. Optimal control strategies are proposed to minimize the cost of interventions. Numerical simulations are given using data from Angola. "Post:Well I wanted to discuss with the OTers around this point in space-time: -I am apriori sympathetic to most keywords in the paper's title: I like optimal control and doing things well, I'm damn sure interested in beating tuberculosis - a family member had it and was cured (phew!) , and I am for helping Angola and such places that certainly need it.-BUT then I get this nagging doubt about the effectiveness of "Numerical Algebra, Control and Optimization" in this pursuit. I can disclose that I am a total ignoramus in every aspect of this except the optimal control bit: I have never cured anyone from any disease in Africa or anywhere, except maybe recommending a hot drink against a cold. Still I get that sad feeling that maybe the effectiveness of the mathematics can be disputed.To make this a really pointless discussion, I will commission first thought before opening the paper:-ODE system is presumably some kind of Volterra equation: is there a parameter for "rate of human deaths per Koch unit"?-minimize the cost of interventions? Are we talking the cost of transport onsite + cost of vaccine? Is space discretized into a finite number of vaccination wards to which the sick flock of their own will, or is there a jab van chasing people all through the streets? I naively thought vaccines were the most expensive part of a vaccination campaign but maybe it IS transports+logistics .-other usual qualms about how are the model parameters estimated, what if i add variables changing my ODE system to a nonholonomic one will that affect propagation, and thus conclusions of the study, wildly?